Diabetes mellitus (DM) is a syndrome characterized by abnormal insulin secretion, derangements in carbohydrate and lipid metabolism, and is diagnosed by the presence of hyperglycemia. In addition to elevated blood glucose levels, increased production of reactive oxygen species (free radicals), which are known to exhibit direct tissue damaging properties, may contribute to a number of diabetic complications such as cardiovascular, blindness, amputations, renal insufficiency, neuronal defects, wound healing and impotency. The world prevalence of diabetes among adults (aged 20–79 years) will be 6.4%, affecting 285 million adults, in 2010, and will increase to 7.7% and 439 million adults by 2030. The long-term complication of diabetes having different pathophysiology and classes according to treat the condition currently different drug therapy is available. This article reviews the complications of diabetes, prevalence, pathogenesis and covers currently available drug therapy for peoples.
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